NFL DFS Week 5 DraftKings Picks: Best Stacks, One-Offs and Leverage from Stokastic’s Sims

With the Week 5 DraftKings main slate approaching, Stokastic’s NFL DFS Sims once again give us a sharp look into where the best NFL DFS picks are coming from. After running the Sims, we analyzed the top 150 lineups (minimum three unique players per build) to identify the most profitable NFL DFS Week 5 picks, stacks, and leverage opportunities.

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NFL DFS Week 5 Picks: Best Stacks and Leverage Plays from Sims

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Quarterback Exposures: Justin Fields Leads the Way

The Sims left little doubt about where the quarterback value sits this week.

• Justin Fields (68 lineups) dominated exposure, making him the clear NFL DFS Week 5 quarterback pick. His rushing ceiling and condensed pass-catching options give him a strong floor/ceiling combo.
• Kyler Murray (25) and Justin Herbert (13) made up the next tier, both bringing stacking potential in higher-total games.
• Deeper leverage plays showed up with Daniel Jones (10) and C.J. Stroud (8), both likely lower-owned in the field but projecting well in Sims.

Takeaway: Fields is the alpha play, but leveraging Murray or Herbert in different stack configurations gives exposure to elite game environments without eating all the chalk.

Running Back Exposures: Achane, White, and Hall Dominate

The RB pool is heavily concentrated:

• De’Von Achane (109 lineups) is the slate’s clear pick at running back. Explosive efficiency paired with growing workload has the Sims screaming value.
• Rachaad White (86) and Breece Hall (72) rounded out the chalk core, with both benefitting from volume-heavy roles. In White’s case, it’s due to Bucky Irving doubtful this week.
• Jahmyr Gibbs (41) showed up as the premium mid-tier pivot, especially in lineups stacking Lions passing games.
• Alvin Kamara (19) and Omarion Hampton (19) are contrarian one-offs in different pricing tiers.

Leverage Note: Ownership on Achane is likely to be massive. Gibbs and Kamara offer direct leverage in lineups that fade the chalk RB construction.

Wide Receiver Exposures: A Balanced Pool with Wilson Leading

Unlike RB, WR exposure spread wider across the pool, signaling more flexibility in builds.

• Garrett Wilson (56 lineups) led the way, firmly entrenched as the top Week 5 WR pick.
• Strong stacking options included Zay Flowers (44), Nico Collins (40), and Jaxon Smith-Njigba (36), all projecting for solid target volume at affordable salaries.
• Chris Olave (34) and Jaylen Waddle (34) both tied as high-ceiling pivots with leverage off chalkier stacks.
• Michael Pittman Jr. (30), A.J. Brown (27), and Amon-Ra St. Brown (27) gave the slate premium WRs in correlated builds.

Contrarian Angles: WRs like George Pickens (20), Marvin Harrison Jr. (18) and Deebo Samuel (18) appeared in enough lineups to warrant attention as mid-tier one-offs.

Tight End Exposures: A Two-Man Show

The Sims made this simple:

• Tyler Warren (55 lineups) and Trey McBride (55) soaked up almost all TE exposure.
• Salary relief plus role stability drove their popularity, while upside plays like Mason Taylor (12) and Jake Ferguson (12) provided GPP pivots.

Takeaway: Paying down at TE is not necessary. Warren and McBride are both highly optimal and relatively expensive.

Defense/Special Teams: Saints Chalk

DST exposure centered heavily on one option:

• Saints (62 lineups) were by far the most popular, followed by Lions (22) and Texans (14).
• Lower exposure one-offs included Seahawks (11) and Colts (10).

Best NFL DFS Week 5 Stacks

Looking at stack exposures, a few game environments stand out:

1. Justin Fields + Garrett Wilson
   • Fields paired with stud WR makes for concentrated volume stacks.
2. Kyler Murray + Marvin Harrison Jr.
   • This combo offers mid-range ownership with strong correlation.
3. C.J. Stroud + Nico Collins
   • Lower-owned premium stack with elite ceiling outcomes.

One-Offs & Leverage Plays

• Jahmyr Gibbs: At half the exposure of Hall/White, Gibbs is the premium RB leverage pivot.
• Chris Olave: A high-upside WR overlooked compared to chalk like Wilson and Flowers.
• Mason Taylor/Jake Ferguson: Salary-saving pivots at TE when Warren/McBride are over-owned.
• Seahawks DST: Sub-10% owned pivot to break away from Saints chalk.