Week 6 is shaping up to be one of those slates where balance beats flashiness. The latest Stokastic NFL DFS Sims show a cluster of mid-tier quarterbacks, a few underpriced bell-cow backs and a handful of wideouts quietly dominating projections. The numbers tell a clear story: This isn’t a stars-and-scrubs week. The best NFL DFS picks come from lineups that feel uncomfortable at first glance, but those are often the ones that win. So before you chase another 15%-owned stack, let’s dig into what the top 150 simulated lineups actually reveal about how to attack the NFL DFS Week 6 slate.
NFL DFS Week 6 Picks: Best Stacks and Leverage Plays from Sims
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Quarterbacks: The Value Tier Rules Week 6
The most common quarterback exposures were split across several mid-range signal-callers, and that tells us a lot about this slate.
- Mac Jones (27 lineups)
- Trevor Lawrence (27)
- Bryce Young (24)
- Sam Darnold (19)
- Drake Maye (15)
It’s unusual to see five quarterbacks grouped this tightly, but it reflects the salary-balanced builds that Sims favored. Mac Jones and Trevor Lawrence led the way with efficient, stackable game environments, while Bryce Young and Sam Darnold appeared as cheaper contrarian pivots with upside.
Leverage note: The Sims see little reason to spend up at QB this week. That creates an exploitable ownership gap if those studs underperform.
Running Backs: Javonte Williams Headlines a Deep Pool
The Sims screamed confidence in one player above all others.
- Javonte Williams (105 lineups) – elite volume and price efficiency.
- Christian McCaffrey (61) – the premium pay-up option.
- Rico Dowdle (52) and Josh Jacobs (52) – strong mid-tier anchors.
- Rachaad White (45) – steady floor play with pass-game involvement.
- Kyren Williams (35) – leverage off Rams passing stacks.
- Travis Etienne Jr. (22) – correlated with Lawrence builds.
Javonte Williams’ role continues to shine through in the Sims. He projects as the slate’s top NFL DFS Week 6 RB pick, with massive usage and salary relief. Meanwhile, McCaffrey remains a high-upside one-off or stack anchor, but Stokastic’s data suggests balanced builds outperform full studs-and-scrubs constructions.
Leverage note: Kyren Williams and Etienne offer direct leverage on the more popular RB trio (Javonte/White/Jacobs). Both appear in lower-owned stacks that still rate highly in Sims.
Wide Receivers: Puka Nacua and Chris Olave Lead the Way
This week’s WR pool is diverse but top-heavy, with a few elite performers emerging clearly above the rest.
- Puka Nacua (91 lineups)
- Chris Olave (69)
- Tetairoa McMillan (38)
- Jaylen Waddle (37)
- Jaxon Smith-Njigba (33)
Nacua appears in over 60% of the top 150 lineups, easily the No. 1 pick at WR. His target share and role stability make him a core play in all formats.
Mid-tier and contrarian WRs:
- Stefon Diggs (24) and Cooper Kupp (23) are premium pivots.
- Brian Thomas Jr. (17) and Davante Adams (13) appear as one-off upside plays.
- Demarcus Robinson (10) and Dontayvion Wicks (11) pop as pure salary savers to unlock studs elsewhere.
Tight Ends: A Wide Mix of Options
- Trey McBride (37)
- Jake Tonges (36)
- Tyler Warren (28)
- Hunter Long (26)
- Tucker Kraft (15)
Trey McBride remains the alpha TE value for the second straight week, tied closely to Arizona stacks and showing the highest overall ROI. Jake Tonges is the mid-tier play that enables top-heavy builds.
Leverage note: If McBride approaches 25%+ ownership, Long and Warren will be efficient pivots. Both appear in double-digit top-150 lineups with similar ceilings per dollar.
DST: Dolphins Chalk, But There’s Room to Pivot
Defense exposure was concentrated heavily around one team:
- Dolphins (63 lineups) – chalky.
- Saints (26) – viable pivot in lower-scoring game scripts.
- Titans (21) – matchup-driven, low-salary leverage.
Best NFL DFS Week 6 Stacks
Stacking was relatively narrow across simulations, centered on three main team archetypes:
- Mac Jones + Jake Tonges + Christian McCaffrey
- Low ownership at quarterback, elite floor from high-volume skill player.
- Trevor Lawrence + Hunter Long + Travis Etienne Jr.
- Correlated upside.
- Bryce Young + Tetairoa McMillan
- Contrarian salary saver stack with upside in game environments the field may overlook.
One-Offs and Leverage Plays
- Kyren Williams: Perfect GPP pivot away from McCaffrey and Williams chalk.
- Chris Olave: High ceiling, high ownership.
- Tyler Warren: Slightly lower-owned option at tight end when McBride is over-owned.
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