MLB DFS Picks, Spotlight Pitchers & Top Stacks: Coors Field Alternatives! (May 6)

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Tuesday brings a 12-game featured slate with a 7:05 first pitch on DraftKings and FanDuel. Yahoo is locking at 6:40 p.m. ET, with a 15-game docket. Today we’re breaking down MLB DFS picks using Stokastic’s industry-leading tools and MLB DFS projections to learn how to build MLB DFS stacks, find the top pitchers and craft optimal daily fantasy baseball lineups RHPs Paul Skenes and Seth Lugo are the key arms and according to the Stokastic MLB DFS Top Stacks Tool, the Kansas City Royals and West Sacramento Athletics are the Coors Field countermoves.

MLB DFS Picks: Spotlight Pitchers and Top Stacks | May 6


MLB DFS Picks: Spotlight Pitchers

Main Slate Primary Pitching Target: RHP Paul Skenes (PIT at STL)

Pirates at Cardinals – 3.7 implied runs
First Pitch: 7:40 p.m. ET
$10,000 at DraftKings
$10,800 at FanDuel
$52 at Yahoo

The Stokastic MLB DFS Top Pitchers tool has RHP Paul Skenes rating out with the best fantasy potential for Tuesday. The pitching phenom is bringing his six-pitch arsenal to St. Louis, while looking to shake off his worst start of the season.

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In the preceding paragraph, the word “worst” is doing a lot of heavy lifting considering, that Skenes gave up a trio of taters to the best offense in the league, though those were the only runs scored by the Chicago Cubs.

The 22-year-old also tied a career-high with four walks, yet still battled through five innings against the Cubbies. In his previous start, he blanked the Dodgers in Los Angeles for 6.1 frames, with nine strikeouts.

St. Louis has been a little above league-average this season against right-handed hurlers, though it isn’t anything that Skenes shouldn’t be able to handle. This will be the fifth-time in his career that the budding superstar has faced the Redbirds and the second time for the season.

The other anchor arm for Tuesday’s tilts is LHP Chris Sale at home against Cincinnati. The Reds are getting a ballpark downgrade from their home venue, plus the batters in the heart of the order, Elly De La Cruz (30.1%, 269 PAs), Matt McLain (27.6%, 29 PAs) and Noelvi Marte (36.6%, 71 PAs) have been happy with their hacks over the last season-plus against southpaws.

Sale can make his own magic, boasting a 31.5% combined strikeout rate in the same timeframe. Plus the reigning National League Cy Young Award winner tabulated 10 strikeouts in Coors Field on Wednesday, ceding just two runs and five hits in seven innings of action.

Main Slate Secondary Pitching Target: RHP Seth Lugo (KC vs. CHW)

Royals vs. White Sox 3.2 implied runs
First Pitch: 7:40 p.m. ET
$8,700 at DraftKings
$9,200 at FanDuel
$45 at Yahoo

Tonight RHP Seth Lugo is the lucky pitcher who is facing the Chicago White Sox. On Monday, LHP Cole Ragans racked up 11 strikeouts in five innings, combining with four relievers to shut out the Pale Hose. The dichotomy of going from Ragans to Lugo is drastic, which should keep the ChiSox off balance the first time through the order.

The Southsiders are fourth in the league with a 10.6% walk rate against right-handed pitching, but they are the third-worst with run creation and have the second-lowest advanced power metrics. Lugo is coming off a career-season, with the 34-year-old making his first All-Star team, earning his first Golden Glove Award and finishing second in the American League Cy Young Award race. The salary may seem a touch high, particularly compared to Sale on DraftKings, but it is definitely valid when considering all the variables.

MLB DFS Picks: Top Stacks

Main Slate Primary Target: Athletics

Athletics vs. Mariners – 5.3 implied runs
First Pitch: 10:05 p.m. ET
Opposing Starter: RHP Emerson Hancock
DK Top Stack %: 6.4%
FD Top Stack %: 7.2%

The Stokastic MLB DFS Top Stacks Tool is uncertain with the weather in Colorado, which makes the Athletics a perfect fallback option, since they are hosting Seattle in the last game of the night. On Monday, the teams went into extra-innings, with five relievers seeing action after starter Bryce Miller managed to complete only four frames, on 94 pitches.

Injuries to Logan Gilbert and George Kirby have forced the Mariners to turn to RHP Emerson Hancock as a regular in the rotation. Even though he was the sixth-overall selection in the 2020 MLB Draft, the soon-to-be 26-year-old has not shown much promise. He has a mid-90s fastball, but weak secondary offerings that lead to inefficient innings and worst case, walks. Most season long projection systems (ZiPS, Steamer, The Bat) have him in the 6.4-to-6.6 strikeouts per nine innings range, with 1.3-to-1.4 home runs per nine. Those are all the ingredients needed for a potential disaster against a power-laden team like the A’s.

The only knocks against the A’s are inexplicably keeping Miguel Andujar in the heart of the order and an overall lack of baserunners. The team has the sixth-most home runs thus far and the fifth-most total base, though they rank 14th for runs scored with 4.36 per game. Andujar is truly the only real weak link in the lineup, with a .290 wOBA and .089 ISO in his last 334 plate appearances against same-handed hurlers.

Youngsters Jacob Wilson and Nick Kurtz have decent contact and will develop power in time, with Lawrence Butler, Brent Rooker, Tyler Soderstrom, JJ Bleday and catcher Shea Langeliers already polished producers.

Main Slate Secondary Target: Kansas City Royals

Royals vs. White Sox – 5.2 implied runs
First Pitch: 7:40 p.m. ET
Opposing Starter: RHP Sean Burke
DK Top Stack %: 6.6%
FD Top Stack %: 7.2%

Do not let RHP Sean Burke’s 2.20 ERA in his last three starts fool you, because it ignores four unearned runs. On the season, he has a 4.91 ERA, with a 7.53 xERA and 5.85 FIP. He has a nice fastball, but command is an issue as is staying healthy. Since joining the White Sox in 2021, he has managed to log only 285.1 innings between the minors and The Show.

Kansas City has a very specific trio to target against right-handed pitching, with superstar Bobby Witt Jr., veteran Salvador Perez and slugger Vinnie Pasquantino. Typically the fourth player for stacks would be Michael Massey, though he has been in a season long slump against opposite-handed hurlers. In a twist, Maikel Garcia has been en fuego against fellow righties, with a wicked .380 wOBA and .194 ISO, compared to his anemic results last year with a .270 wOBA and a .086 ISO, he is like an entirely different player.

Today’s Top Sports Betting Picks

If you’re serious about making sharp MLB DFS picks, you already know that long-term success starts with using the right tools. The same approach applies to sports betting — and that’s where Portfolio EV shines.

Take Tony Gonsolin under 4.5 strikeouts, for example. This is a +EV bet, meaning it has positive expected value based on the best odds available. But smart betting with Portfolio EV isn’t about chasing isolated plays; it’s about consistently firing off a high volume of +EV wagers. With the Mass Entry tool, you can scale your action and let the math compound your edge over time.

Just like one DFS lineup won’t guarantee a takedown, one bet won’t define your night — it’s the consistent process that leads to profit.

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Gonsolin has never really had sustained success, since debuting in 2019 as a top prospect for the Dodgers. He underwent Tommy John surgery in 2023, missing all 2024, aside from a couple rehabilitation appearances in the minors. This year he hurt his back lifting weights at spring training, keeping him out of action for more than a month to start the season. He will be celebrating his 31st birthday next week and the projected Miami lineup has a scant 18.1% strikeout rate against right-handed hurlers over the last season and change. Enjoy!

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Eric "EMac" MacPherson won the 2007 Fantasy Baseball grand prize (trip for two to the MLB All-Star game) in the Roto format on ESPN. He won again in 2008, this time in the H2H format. As one of the early adopters of daily fantasy sports, EMac has been providing content for baseball and basketball as well as both professional and college football since 2012 for a variety of websites including DraftKings Playbook, FanVice, RotoWorld, Daily Fantasy Bootcamp, and RotoGrinders. He is well into his third decade of fantasy sports and has a wealth of knowledge and experience. Follow him on Twitter @EMacDFS or contact EMac by emailing [email protected].

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