In NFL DFS, nothing matters early in the week until that Friday injury report drops because everything can change in an instant. In this week’s Perfect Lineup, we dig into the evolving Week 10 slate, building three unique lineups and running them through the Single Lineup Simulator to search for the elusive NFL DFS perfect lineup: The blend of projection, leverage and ceiling NFL DFS picks that separates winners from the field.
NFL DFS Week 10 Picks: Build the Perfect DraftKings Lineup with Sims
Lineup 1: Drake Maye and the Patriots Value Stack
When injuries hit New England, opportunity opened for sharp players. With Rhamondre Stevenson and Kayshon Boutte sidelined, the Patriots’ passing tree condensed around Drake Maye, DeMario Douglas and Hunter Henry, a trio combining low salary with stackable upside.
Douglas is wildly underpriced at $4,000 after commanding a steady target share, while Henry provides cheap red zone exposure. We ran the build back with Emeka Egbuka, who should benefit with Chris Godwin and Bucky Irving out for Tampa Bay. The matchup projects as one of the week’s sneaky shootouts, with a short spread and two offenses forced to throw.
Lineup 2: The Lamar Jackson Bounce-Back
For the second build, we returned to a proven pairing: Lamar Jackson with Zay Flowers, adding Isaiah Likely as a contrarian tight end pivot. While most players will flock to Mark Andrews, Likely offers leverage and savings at $2,900, with the added benefit of uniqueness in a popular stack.
Jackson’s mobility is unmatched, and Flowers’ price tag below $6,000 keeps the combo affordable. This setup allowed us to fill the remaining roster with chalk value like De’Von Achane, Rico Dowdle, Christian McCaffrey, Khalil Shakir and Douglas without sacrificing differentiation.
Lineup 3: Jaxson Dart Value Stack with Stars Up Top
The final build went back to Jaxson Dart, pairing him with Wan’Dale Robinson for salary relief. The logic is simple: Dart carries real rushing upside, Robinson functions as an extension of the run game with short PPR-friendly targets and the savings unlock elite skill players elsewhere.
From there, we loaded up with Achane, Dowdle and Amon-Ra St. Brown, a core capable of producing tournament-winning ceilings. Achane’s workload spike and game-script versatility make him a fixture in Week 10 NFL DFS picks, while St. Brown provides 30-point potential in a favorable matchup against Washington.
Lineup 1 – Patriots Stack
Lineup 2 – Ravens Stack
Lineup 3 – Giants Stack
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Build Your Own Perfect Lineup: Sims Find the Best NFL DFS Picks
The Perfect Lineup process lives inside Stokastic NFL Sims, featuring the Single Lineup Simulator, Pre-Contest Sims, ownership projections and stack analysis that power these builds.
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