Some call it generous; others call it madness. With so many viable quarterback options on this slate, NFL DFS Week 12 brings not one, not two, but three Perfect Lineup builds, plus a few bonus lineups for the main slate. In this week’s edition, we build the cores and stacks then run the Single Lineup Simulator to see which combinations of projection, leverage, and ceiling come closest to creating the perfect NFL DFS lineup. Let’s dive into the picks for today.
NFL DFS Week 12 Picks: Build the Perfect DraftKings Lineup with Sims
Don’t leave value on the table. Unlock +EV bets with a FREE TRIAL of Portfolio EV — visit the Portfolio Betting page now!
Lineup 1: Patrick Mahomes and the Chiefs Stack
The Kansas City Chiefs enter Week 12 at 5-5 and desperate for a spark. The matchup looks tough on paper, but context matters: This game has a 50.5-point total and the Chiefs own one of the highest implied team totals on the slate (27 points). Even with injuries and uneven production, Patrick Mahomes remains the top quarterback option for tournament upside.
We started with a core of Mahomes, Rashee Rice and Travis Kelce, then added Alec Pierce as the runback. Pierce leads the Colts in target share (26%) and air yards (59%) over the last month, giving him sneaky upside at a low salary.
Lineup 2: Jared Goff Triple Stack
Triple stacks don’t hit often, but when they do, they separate you from the field. We leaned into this with Jared Goff featuring Amon-Ra St. Brown, Jahmyr Gibbs and Jameson Williams. The Lions are double-digit home favorites against the Giants, and every time Detroit has suffered a bad loss, it responded with an offensive explosion the following week.
With Sam LaPorta on injured reserve, Goff’s target tree has narrowed dramatically. Last week, 81% of his pass attempts went to St. Brown, Gibbs and Williams.
Lineup 3: Drake Maye and the Patriots Stack
For the third lineup, we went back to the well with a Drake Maye stack, a contrarian pivot that brought surprising balance. The setup included Stefon Diggs, Hunter Henry, and Chase Brown as the bring-back.
The logic is simple: Henry draws a dream matchup against a Bengals defense that already surrendered eight touchdowns to tight ends, most in the league. Diggs, meanwhile, just posted a 100-yard outing against the Jets and remains the clear No. 1 target. Chase Brown is seeing workhorse usage in Cincinnati’s backfield, recording 50-plus combined touches in the past two games with Samaje Perine out.
Check out our breakdown of our NFL subscriptions for pricing and a detailed overview of the NFL DFS picks tools and data.
Build Your Own Perfect Lineup: Sims Find the Best NFL DFS Picks
The Perfect Lineup process lives inside Stokastic NFL Sims, featuring the Single Lineup Simulator, Pre-Contest Sims, ownership projections and stack analysis that power these builds.
Use promo code PERFECT to get 15% off any monthly NFL Sims Max or Core package and start running your own NFL DFS picks through the same simulation engine.
