If you thought pricing was soft in Week 1, wait until you dive into NFL DFS picks for Week 2. DraftKings salaries have opened the door to creative, high-upside roster construction, and the right stack could be the difference between a min-cash and a first-place finish. In this breakdown, we’re using Stokastic’s NFL DFS Single Lineup Simulator to test three complete builds, each crafted to help you chase the elusive NFL DFS perfect lineup.
NFL DFS Week 2 Picks: Build the Perfect DraftKings Lineup with Sims
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49ers Onslaught: Extreme Value, Tournament Leverage
The first lineup goes all-in on the 49ers, and yes, it starts with Mac Jones at quarterback. With Brock Purdy out, Jones steps into a loaded San Francisco offense and costs the minimum $4,000 on DraftKings. While he’s not a flashy pick, the value he unlocks is massive.
Jones is stacked with Christian McCaffrey, Ricky Pearsall and Jauan Jennings. That full stack costs just $21,600, giving you over $6,500 per player for the remaining four spots. For context, McCaffrey alone has a rushing + receiving prop of 118.5 yards and is -180 to score a touchdown, yet he’s only $7,500. That kind of mispricing is the foundation of a true NFL DFS perfect lineup.
Stokastic’s Sims returned a 140% ROI on this build, with a 0.5% chance to win the entire contest and a 40% cash rate. It also pulls in high-upside pieces from other games like Tony Pollard, Puka Nacua and the Ravens defense to maximize tournament viability.
This is the kind of DFS lineup that thrives in soft-pricing slates: Cheap quarterback, elite correlation and ceiling everywhere else.
Jaguars-Bengals Stack: Smart Construction, Unique Leverage
For the second lineup, we’re targeting a popular game (Jaguars-Bengals) but taking an uncommon approach to stacking it. Instead of a double-stack with a single runback, we use a skinny stack with Trevor Lawrence and Brian Thomas Jr. then run it back with two Bengals: Ja’Marr Chase and Chase Brown.
This build breaks from standard NFL DFS Week 2 picks patterns. While others gravitate toward Joe Burrow-Chase doubles, this version allows you to leverage the same game environment without overlapping roster structures.
Brown’s usage is key here. He handled all of the Bengals’ running back carries in Week 1 and looks like a bell cow going forward. Chase, meanwhile, is coming off a quiet opener, but his role remains unchanged, and his bounce-back potential is huge. This game has a 50-point total with a 3.5-point spread, making it one of the best shootout spots on the slate.
If you’re looking to be different while still attacking a high-total game, this is one of the sharper NFL DFS Week 2 picks you can make.
Cardinals + Dolphins Mini Stack: Betting on the Bounce Back
The final lineup gets weird, in a good way. It starts with a Cardinals stack: Kyler Murray paired with Marvin Harrison Jr. and Trey McBride against the Panthers. But the real edge is in the mini stack: Tyreek Hill and De’Von Achane.
After a letdown in Week 1, Miami is being overlooked. That makes them one of the sharpest contrarian spots on the board. The Patriots secondary is without Christian Gonzalez, and the Dolphins are slight home favorites with a respectable 23-point implied total.
Hill always carries 30-point upside, and Achane is explosive enough to house any touch. Stacking them without Tua Tagovailoa helps you capture upside without committing to the full passing attack. Add in Murray, Harrison and McBride for a relatively cheap, concentrated stack, and you have a build that could separate if both spots hit.
Using Stokastic’s Single Lineup Simulator, these stacks were run through a three-max entry approach:
Lineup 1 – Loaded 49ers Stack
Lineup 2 – Add 10% Randomness with Jaguars-Bengals Game Stack
Lineup 3 – Cardinals Stack + 10% Randomness
Week 2 is the best time to get aggressive. Pricing is loose, ownership is reactive, and the field is likely to overcorrect based on Week 1 performances.
