There is an NFC West showdown on Monday Night Football, with the Los Angeles Rams taking on the San Francisco 49ers. Both teams will be looking to get back into the win column after both suffered losses last week, but which team will prevail? The following Rams vs. 49ers NFL betting picks preview will provide the current odds, betting trends and best NFL bets for the Week 10 Monday Night Football matchup.
NFL Best Bets & Odds: Week 10 Monday Night Football
Los Angeles Rams vs. San Francisco 49ers
Date: Monday, Nov. 15, 2021
Time: 8:15 p.m. EST
Venue: Levi’s Stadium — Santa Clara, Calif.
Coverage: ESPN
The Rams have had an interesting couple of weeks. First, they traded for Von Miller to make their defensive line incredibly scary. He ended up not playing in the game, and they got crushed by the Titans. Then the Rams won the Odell Beckham Jr. sweepstakes, only to have their WR2, Robert Woods, tear his ACL the following day. They still look like one of the best teams in the NFL this season, and that is clearly what they are hoping to be. They have pushed all of their chips to the center, making this season “Super Bowl or bust.”
The 49ers, on the other hand, are looking like they are about to have their fourth losing season of the Kyle Shanahan era, with his lone winning season being the year he went to the Super Bowl. The defense no longer scares anyone, the offense lacks creativity, and Jimmy Garoppolo is clearly not good enough to overcome these other obstacles. This feels like a game they could win to mess with everyone, but they are not a good football team.
Rams vs. 49ers Betting NFL Picks + Odds Shopping
Using Awesemo’s OddsShopper Tool, we can easily compare the NFL odds for Rams vs. 49ers betting across the major sportsbooks. Make sure to check out the OddsShopper tool yourself to get the most up-to-date odds.
Rams vs. 49ers NFL Betting Trends
- Los Angeles is 4-5 against the spread this season.
- The over is 5-3-1 for the Rams this season.
- San Francisco is 2-6 against the spread this season.
- The over is 5-3 for the 49ers this season.
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Rams vs. 49ers Betting Stats
- The Rams are averaging 29.0 points per game this season (No. 4 in the NFL).
- The Rams are surrendering 21.8 points per game this season (No. 11 in the NFL).
- San Francisco is averaging 23.1 points per game this season (T-No. 17 in the NFL).
- San Francisco is surrendering 25.2 points per game this season (No. 24 in the NFL).
Rams vs. 49ers NFL Best Bet
We are using the new Awesemo NFL Betting Model to figure out what the best bet for Monday Night Football is tonight. According to the model, betting the Rams moneyline is the best bet to place, giving it an expected ROI of -1.6%. All of the game bets tonight have expected negative ROIs, but this bet is the least bad, so to speak.
The Rams offensive line was bullied last week, which is why they lost to the Titans. While the 49ers used to have a pass rush that could bully opponents, they have not been that this season. If Matthew Stafford has time in a clean pocket, this game may not be close. However, San Francisco will make some plays at home, which is why taking the moneyline instead of a tricky spread is the best way to go.
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